Deprescribing Tools for Clinicians

For Clinicians


Polypharmacy is common in patients on hemodialysis, increasing the risk of adverse events, medication interaction, nonadherence, and mortality. Deprescribing is one way to minimize the risks of polypharmacy. Although deprescribing guidelines currently exist, they are not medication-specific nor developed specifically for the hemodialysis population.

In response, the STOPMed-HD research team has developed and validated a deprescribing toolkit specific to patients on hemodialysis. The toolkit targets nine medication classes commonly prescribed to this patient population. 

Click here for more details on the project and content validation process

Click here to view relevant publications

The Deprescribing Toolkit

Our validated deprescribing toolkit is an evidence-based and quality-focused initiative consisting of four key features:

1.  Deprescribing Algorithms: Identifies patients taking a potentially inappropriate medication, provides appropriate tapering schedules, highlights key safety and effectiveness parameters, and provides triggers for decision making (flow-chart format)

2.  Evidence Tables: Summaries of the available literature on the safety and efficacy of medications in HD patients, used to inform the creation of our deprescribing algorithms

3.  Monitoring Forms: Printable forms can be inserted into the patient's record for ease of safety monitoring

4.  Patient Information Tools: Supplementary educational material for hemodialysis patients consisting of a video and pamphlet; ensures the patient is appropriately involved in the deprescribing decision

Medications Supported

Alpha-1 Blockers

e.g. Alfuzosin (Xatral®); Doxazosin (Cardura-1®); Prazosin (Minipress®); Silodosin (Rapaflo®); Tamsulosin (Flomax CR®); Terazosin (Hytrin®) 

Benzodiazepines / Z-Drugs

e.g. Alprazolam (Xanax®); Bromazepam (Lectopam®); Chlordiazepoxide (Librium®); Clobazam (Frisium®); Clonazepam (Rivotril®); Clorazepate (Tranxene®); Diazepam (Valium®); Flurazepam; Lorazepam (Ativan®); Midazolam (Versed®); Nitrazepam; Oxazepam (Serax®); Temazepam (Restoril®); Triazolam (Halcion®) 


e.g. Gabapentin (Neurontin® or Auro-Gabapentin®); Pregabalin (Lyrica®) 

Loop Diuretics

e.g. Bumetanide (Burinex®); Ethacrynic acid (Edecrin®); Furosemide (Lasix®) 

Prokinetic Agents

e.g. Domperidone (Motilium®); Linaclotide (Constella®); Metoclopramide (Metonia®, Reglan®); Prucalopride (Resotran®) 

Proton Pump Inhibitors

e.g. Dexlansoprazole (Dexilant®); Esomeprazole (Nexium®); Lansoprazole (Prevacid®); Omeprazole (Losec®, Olex®); Pantoprazole magnesium (Tecta®); Pantoprazole sodium (Pantoloc®); Rabeprazole (Pariet®) 


e.g. Quinine sulfate (Qualaquin®) 


e.g. Atorvastatin (Lipitor®); Fluvastatin (Lescol®); Lovastatin (Mevacor®); Pravastatin (Pravachol®); Rosuvastatin (Crestor®); Simvastatin (Zocor®) 

Urate-Lowering Agents

e.g. Allopruniol (Zyloprim®)

Full Toolkit

Includes clinician tools for all nine medication classes.